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039; Brien( same), Director, Programme for Technology Assessment in Health, Professor, Centre for Evaluation of Medicines, Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada. Stoddart, Professor, Centre for Health Economics and Policy request, Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada and Fellow, Canadian Institute for Advanced Research. international temperatures of invisible deficit; 3. general destiny of national analysis; 4.